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Impotence Cure drugs might help treat oesophageal cancer, research study finds
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22 June 2022
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An active ingredient in erectile dysfunction medication may help deal with oesophageal cancer, a study has actually found.
Southampton scientists found the PDE5 inhibitors in the medication assisted penetrate the barrier of cells around tumours, allowing chemotherapy drugs to reach cancer cells.
One in 10 clients presently makes it through the disease, which is anywhere in the gullet, Cure for Impotence 10 years or more.
The study was funded by Cancer Research UK. The next stage is a clinical trial.
Prof Tim Underwood, lead author of the research study, stated the discovery could improve these survival rates.
He stated a cell understood as the cancer-associated fibroblast, responsible for wound recovery, might be targeted with the inhibitors.
"It's been used throughout the world in millions of dosages," he described. "It's safe, and we applied it to cancer."
He included it was to the scientists "wonder and surprise and pleasure" that the drug had an effect.
"We need to put this into a medical trial where we attempt the drug type alongside chemotherapy to see if it makes the chemotherapy more effective," he said.
"The preliminary work recommends it must do, and if it does and if it's safe, and it improves outcomes of chemotherapy, then it might be truly substantial for the patients I look after."
The study was performed using tumours from eight cancer clients, with additional tests done on mice.
Chemotherapy only helps 20% of oesophageal cancer patients in a significant way, he said.
"If this drug combination even improves it by a small amount, we're actually going to help a big number of people every year to respond better and live longer."
Researchers at Southampton University Hospitals state that the normal results of erectile disorder drugs need additional stimulation, so would not impact cancer clients in the same way.
Prof Underwood stated the main side results would be "a little headache, a little bit of flushing".
Terry Daly, from Aldershot, Hampshire, is one of the 9,500 individuals identified with oesophageal cancer in the UK every year.
It often goes undetected in the early phases, with Mr Daly discovering it was difficult to swallow his food and he ended up regurgitating it.
He is shortly to go through another round of chemotherapy, and said if he had the option to take the new treatment he would have "taken it with both hands".
"The research study that is being done is absolutely fantastic," he stated.
"It is just unbelievable that there are individuals out there happy to spend their lives just searching for a remedy, so that people can proceed with their daily lives and not have to go through all this stuff.
"You can't thank these people enough for what they're doing."
The five-year research study has been funded by Cancer Research UK and the Medical Research Council.
A clinical trial is expected within the next 18 months and if successful, it is hoped new treatments based on this research might be used within ten years.
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Related subjects
Aldershot
Southampton
Cancer
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Related internet links
Cancer Research UK
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What is oesophageal cancer? - NHS
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Impotence Drugs might Assist Treat Oesophageal Cancer, Study Finds
Leanne Grow edited this page 2025-06-03 13:10:56 +08:00